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Important Recent Publications

• • Luque M, Matic M, Heras-Garvin A, Amo-Aparicio J, Luk KC, Haindl MT, Khalil M, Skouras DB, Dinarello CA, Stefanova N. Clinically advanced NLRP3 inhibitor modulates microglial transcriptome and alleviates α-synuclein-induced progression of parkinsonism. J Neuroinflammation. 2026 Jan 31;. doi: 10.1186/s12974-026-03716-3. 
  • Campese N, Qamar MA, Chiriac MA, Göbel G, Wanschitz J, Schlager A, Caliò B, Leys F, Bower P, Zamarian L, Schrag A, Freeman R, Kaufmann H, Granata R, Kiechl S, Poewe W, Seppi K, Wenning G, Chaudhuri KR, Fanciulli A. Types of Pain in Multiple System Atrophy. Mov Disord. 2026 Jan 24. doi: 10.1002/mds.70194. Epub ahead of print. PMID: 41578842.
  • Krismer F, Fanciulli A, Meissner WG, Coon EA, Wenning GK. Multiple system atrophy: advances in pathophysiology, diagnosis, and treatment.Lancet Neurol. 2024 Dec;23(12):1252-1266. doi: 10.1016/S1474-4422(24)00396-X.
  • Chia R, Ray A, Shah Z, Ding J, Ruffo P, et al. Genome sequence analyses identify novel risk loci for multiple system atrophy. Neuron. 2024 Apr 24:S0896-6273(24)00240-X. doi: 10.1016/j.neuron.2024.04.002. Epub ahead of print. PMID: 38701790.
  • Fanciulli A, Stankovic I, Avraham O, Jecmenica Lukic M, Ezra A, et al. Early Screening for the Parkinson Variant of Multiple System Atrophy: A 6-Item Score. Mov Disord Clin Pract. 2024 Apr 24. doi: 10.1002/mdc3.14048. Epub ahead of print. PMID: 38659282.
  • Millar Vernetti P, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Shibao CA,et al. Phenoconversion in pure autonomic failure: a multicentre prospective longitudinal cohort study. Brain. 2024 Feb 15:awae033. doi: 10.1093/brain/awae033. Epub ahead of print. PMID: 38366572.
  • Stefanova N, Wenning GK. Multiple system atrophy: at the crossroads of cellular, molecular and genetic mechanisms. Nat Rev Neurosci. 2023 Jun;24(6):334-346. doi: 10.1038/s41583-023-00697-7. Epub 2023 Apr 21. PMID: 37085728.
  • Cheng A, Kawahata I, Wang Y, Jia W, Wang H et al.Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation. Brain. 2023 Aug 1;146(8):3172-3180. doi: 10.1093/brain/awad137. PMID: 37082980.
  • Stefanova N. A Mouse Model of Multiple System Atrophy: Bench to Bedside. Neurotherapeutics. 2023 Jan;20(1):117-126. doi: 10.1007/s13311-022-01287-8. Epub 2022 Aug 22. PMID: 35995919; PMCID: PMC10119356.
  • Torre-Muruzabal T, Van der Perren A, Coens A, Gelders G, Janer AB, et al. Host oligodendrogliopathy and α-synuclein strains dictate disease severity in multiple system atrophy. Brain. 2023 Jan 5;146(1):237-251. doi:10.1093/brain/awac061. PMID: 35170728.
  • Fanciulli A, Leys F, Lehner F, Sidoroff V, Ruf VC, et al. A multiplex pedigree with pathologically confirmed multiple system atrophy and Parkinson's disease with dementia. Brain Commun. 2022 Jul 4;4(4):fcac175. doi:10.1093/braincomms/fcac175. PMID: 35855480; PMCID: PMC9291376.
  • Wenning GK, Stankovic I, Vignatelli L, Fanciulli A, Calandra-Buonaura G,et al. The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy. Mov Disord. 2022 Jun;37(6):1131-1148. doi:10.1002/mds.29005. Epub 2022 Apr 21. PMID: 35445419; PMCID: PMC9321158.
  • Heras-Garvin A, Refolo V, Schmidt C, Malfertheiner K, Wenning GK, et al. ATH434 Reduces α-Synuclein-Related Neurodegeneration in a Murine Model of Multiple System Atrophy. Mov Disord. 2021 Nov;36(11):2605-2614. doi: 10.1002/mds.28714. Epub 2021 Jul 8. PMID: 34236731.
  • Lemos M, Venezia S, Refolo V, Heras-Garvin A, Schmidhuber S, et al. Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance. Transl Neurodegener. 2020 Sep 24;9(1):38. doi: 10.1186/s40035-020-00217-y. PMID:32972456; PMCID: PMC7513530.
  • Herrera-Vaquero M, Heras-Garvin A, Krismer F, Deleanu R, Boesch S, et al. Signs of early cellular dysfunction in multiple system atrophy. Neuropathol Appl Neurobiol. 2021 Feb;47(2):268-282. doi: 10.1111/nan.12661. Epub 2020 Sep 17. PMID: 32892415; PMCID: PMC7891639.
  • Heras-Garvin A, Weckbecker D, Ryazanov S, Leonov A, Griesinger C, et al. Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy. Mov Disord. 2019 Feb;34(2):255-263. doi: 10.1002/mds.27562. Epub 2018 Nov 19. PMID: 30452793; PMCID: PMC6492169.
  • Refolo V, Bez F, Polissidis A, Kuzdas-Wood D, Sturm E, et al. Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies. Acta Neuropathol Commun. 2018 Jan 3;6(1):2. doi: 10.1186/s40478-017-0504-y. PMID: 29298733; PMCID: PMC5753576.

All Publications in PubMed.

Book recommendation   

	Multiple System Atrophy Wenning, Gregor K., Fanciulli, Alessandra (Eds.) 2014, XVI, 198 p. 33 illus., 20 illus. in color.