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Prof. Dr. Alexander Hüttenhofer Lab

Univ. Prof. Alexander Hüttenhofer

Univ. Prof. Alexander Hüttenhofer

Director
alexander.huettenhofer@i-med.ac.at

Curriculum vitae

Research topics

My group works on the identification and function of small non-coding RNAs (ncRNAs) in various model organisms for which we have coined the term “Experimental RNomics“. By this approach we are, in particular, interested in the involvement of ncRNAs in the etiology of human diseases.

Most recent publications 

Truncated variants of MAGEL2 are involved in the etiologies of the Schaaf-Yang and Prader-Willi syndromes

Selected publications

  1. Cavaille J, Buiting K, Kiefmann M, Lalande M, Brannan C, Horsthemke B, Brosius, J. and Hüttenhofer, A. Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization. Proc Natl Acad Sci U S A. 2000;97(26):14311–6. First discovery of a brain-specific ncRNA causing Prader-Willi Syndrome
  2. Hüttenhofer A, Kiefmann M, Meier-Ewert S, et al. RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse. EMBO J. 2001;20(11):2943-2953. doi:10.1093/emboj/20.11.2943. First RNAseq approach to identify novel ncRNAs in model organisms.
  3. Tang T-H, Bachellerie J-P, Rozhdestvensky T, Bortolin M-L, Huber H, Drungowski M, Elge, Th, Brosius, J and Hüttenhofer, A. Identification of 86 candidates for small non-messenger RNAs from the archaeon Archaeoglobus fulgidus. Proc Natl Acad Sci U S A. 2002 99(11):7536–41. First description of the transcription and processing of CRISPR RNAs.
  4. Washietl, S., Hofacker, I., Lukasser, M., Hüttenhofer, A. and Stadler, P. F. Mapping of conserved RNA secondarystructures predicts thousands of functional noncoding RNAs in the human genome (2005) Nature Biotechnology, 23, 1383-1390.
  5. Hüttenhofer A, Schattner P, Polacek N. Non-coding RNAs: hope or hype? Trends in Genetics. 2005 May;21(5):289–97.
  6. Mrazek, J., Kreutmayer, S. B., Grässer, F. A., Polacek, N. and Alexander Hüttenhofer, (2007) Subtractive hybridization identifies novel differentially expressed ncRNA species in EBV- infected human B cells. Nucleic Acids Res., 35,
  7. Hutzinger, R., Feederle, R., Mrazek. J., Schiefermeier. , Balwierz. P.J., Zavolan, M., Polacek, N., Delecluse, H.J. and Hüttenhofer, A. (2009) Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome, PLOS Pathogens, 5 First discovery of a nuclear snoRNA gene within the viral EBV genome.
  8. Skreka, K. et al. Identification of differentially expressed non-coding RNAs in embryonic stem cell neural differentiation. Nucleic Acids Res (2012).doi:10.1093/nar/gks311
  9. Thomas Philipp Hoernes, Klaus Faserl, Michael Andreas Juen, Johannes Kremser, Catherina Gasser, Elisabeth Fuchs, Xinying Shi, Aaron Siewert, Herbert Lindner, Christoph Kreutz, Ronald Micura, Simpson Joseph, Claudia Höbartner, Eric Westhof, Alexander Hüttenhofer & Matthias David Erlacher (2018) Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions. Nature Communications. 2018 Nov 19;9(1):3497–12.
  10. Grimm, C., Hillen, H.S., Bedenk, K., Bartuli, J., Neyer, S., Zhang, Q., Hüttenhofer, A., Erlacher, M., Dienemann, C., Schlosser, A. et al. (2019) Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes. Cell, 179, 1537-1550.e1519. First discovery that a tRNA is an integral component of the vaccinia polymerase.
  11. Hoser SM, Hoffmann A, Meindl A, Gamper M, Fallmann J, Bernhart SH, et al. Intronic tRNAs of mitochondrial origin regulate constitutive and alternative splicing. Genome Biology. 2020;21(1):299.This paper, for the first time, describes a function of mitochondrial DNA (i.e mitochondrial tRNA gene homologs) in the nuclear genome.

Hüttenhofer Lab