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home>rnomics>erlacher-lab

Prof. Dr. Matthias Erlacher Lab

Univ. Prof. Matthias Erlacher

Univ. Prof. Matthias Erlacher

Associate Director
matthias.erlacher@i-med.ac.at

Research topics

Ribosomes are multifunctional ribonucleo-protein (RNP) complexes that translate the genetic information in form of mRNA into proteins. Therefore, protein synthesis is essential in all living organisms and requires an orchestrated interplay of numerous molecules. Our aim is to contribute to a better understanding of the molecular interactions during translation. We use modified RNAs to manipulate interplay between mRNA, tRNA and rRNA and determine their impact on different step of protein synthesis.

Selected publications

  1. Maria Kompatscher, Karolina Bartosik, Kevin Erharter, Raphael Plangger, Fabian Sebastian Juen, Christoph Kreutz, Ronald Micura, Eric Westhof and Matthias D. Erlacher* (2024). Contribution of tRNA sequence and modifications to the decoding preferences of E. coli and M. mycoides tRNAGly (UCC) for synonymous glycine codons. Nucleic Acids Res. 52(3): 1374-1386. Doin: 10.1093/nar/gkad1136
  2. Maximilian P. Kohl, Maria Kompatscher, Nina Clementi, Lena Holl, Matthias D. Erlacher* (2023). Initiation at AUGUG and GUGUG sequences can lead to translation of overlapping reading frames in E. coli (2023). Nucleic Acids Res. 51 (1):271-289; doi.:10.1093/nar/gkac1175
  3. Olga A. Krasheninina, Julia Thaler, Matthias D. Erlacher and Ronald Micura (2021). Amine-to-Azide Conversion on Native RNA via Metal-Free Diazotransfer Opens New Avenues for RNA Manipulations. Angew Chem Int Ed Engl. 60 (13):6970-6974; doi: 10.1002/anie.202015034
  4. Clemens Grimm, Hauke S. Hillen, Kristina Bedenk, Julia Batuli, Simon Neyer, Qian Zhang, Alexander Hüttenhofer, Matthias D. Erlacher, Christian Dienemann, Andreas Schlosser, Henning Urlaub, Bettina Böttcher, Aladar A. Szalay, Patrick Cramer, and Utz Fischer (2019). Sructural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes. Cell 179(7):1537-1550; doi: 10.1016/j.cell.2019.11.024
  5. Thomas P. Hoernes, David Heimdörfer, Daniel Köstner, Klaus Faserl, Felix Nußbaumer, Raphael Plangger, Christoph Kreutz, Herbert Lindner, and Matthias D. Erlacher* (2019). Eukaryotic translation elongation is modulated by single natural nucleotide derivatives in the coding sequences of mRNAs. Genes 10, 84; doi: 10.3390/genes10020084
  6. Thomas P. Hoernes, Klaus Faserl, Michael A. Juen, Johannes Kremser, Catherina Gasser, Elisabeth Fuchs, Xingying Shi, Aaron Siewert, Herbert Lindner, Christoph Kreutz, Ronald Micura, Simpson Joseph, Claudia Höbartner, Eric Westhof, Alexander Hüttenhofer, Matthias D. Erlacher* (2018). Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions. Nat Commun. Nov 19;9(1):4865; doi: 10.1093/nar/gkv1182
  7. Thomas P. Hoernes, Nina Clementi, Michael A. Juen, Xinying Shi, Klaus Faserl, Jessica Willi, Catherina Gasser, Christoph Kreutz, Simpson Joseph, Herbert Lindner, Alexander Hüttenhofer and Matthias D. Erlacher* (2018). Atomic mutagenesis of stop codon nucleotides reveals the chemical prerequisites for release factor-mediated peptide release. PNAS 16;115(3): E382-E389; doi: 10.1073/pnas.1714554115
  8. Modi Safra, Aldema Sas-Chen, Ronit Nir, Roni Winkler, Aharon Nachshon, Dan Bar- Yaacov, Matthias D. Erlacher, Walter Rosmanith, Noam Stern-Ginossar, Schraga Schwartz (2017). The m1A landscape on cytosolic and mitochondrial mRNA at single- base resolution. Nature 551 (7679): 251-255; doi: 10.1038/nature24456
  9. Pius Schrode, Paul Huter, Nina Clementi and Matthias D. Erlacher* (2017). Atomic mutagenesis at the ribosomal decoding site. RNA Biol. 14(1):104-112; doi: 10.1080/15476286.2016.1256535
  10. Thomas P. Hoernes, Nina Clementi, Klaus Faserl, Heidelinde Glasner, Katrin Breuker, Herbert Lindner, Alexander Hüttenhofer*, Matthias D. Erlacher* (2016). Nucleotide modifications within bacterial mRNAs regulate their translation and are able to rewire the genetic code. Nucleic Acids Res. 44(2):852-62; doi: 10.1093/nar/gkv1182
  11. Matthias D. Erlacher#, Anna Chirkova#, Paul Vögele and Norbert Polacek (2011). Generation of chemically engineered ribosomes for atomic mutagenesis studies on protein biosynthesis. Nature Protocols 6 (5): 580-592; doi: 10.1038/nprot.2011.306 #...contributed equally

 

Erlacher Lab